Biochemical and developmental effects of thyroid and anti-thyroid drugs on different early life stages of Xenopus laevis
Autor: | Abbas Güngördü, Filiz Boran |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Embryo Nonmammalian Health Toxicology and Mutagenesis Levothyroxine Xenopus Embryonic Development Biology Toxicology Carboxylesterase Xenopus laevis Antithyroid Agents Internal medicine medicine Animals Glutathione Transferase Pharmacology Thyroid Metamorphosis Biological Embryo General Medicine biology.organism_classification Tadpole Thyroxine Glutathione Reductase Teratogens Endocrinology medicine.anatomical_structure Propylthiouracil Larva Toxicity Acetylcholinesterase Female medicine.drug Hormone |
Zdroj: | Environmental Toxicology and Pharmacology. 87:103738 |
ISSN: | 1382-6689 |
Popis: | The effects of two drugs containing the synthetic thyroid hormone levothyroxine (LEV) and an anti-thyroid drug containing propylthiouracil (PTU) on the three early life stages of Xenopus laevis were evaluated with the Frog Embryo Teratogenesis Assay-Xenopus, Tadpole Toxicity Test, and Amphibian Metamorphosis Assay using biochemical and morphological markers. Tested drugs caused more effective growth retardation in stage 8 embryos than stage 46 tadpoles. Significant inhibition of biomarker enzymes has been identified in stage 46 tadpoles for both drugs. AMA test results showed that LEV-I caused progression in the developmental stage and an increase in thyroxine level in 7 days exposure and growth retardation in 21 days exposure in stage 51 tadpoles. On the other hand, increases in lactate dehydrogenase activity for both drugs in the AMA test may be due to impacted energy metabolism during sub-chronic exposure. These results also show that the sensitivity and responses of Xenopus laevis at different early developmental stages may be different when exposed to drugs. |
Databáze: | OpenAIRE |
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