Long Term Low Molecular Weight Heparin Anticoagulant Therapy Modulates Thrombin Generation and D-dimer in Patients with Cancer and Venous Thromboembolism

Autor: Anna Falanga, Andrea D'Alessio, Kim W.F.M. Lambregts, Laura Russo, Sara Cecchini, Marina Marchetti, Daniela Di Mauro, Carmen J Tartari
Přispěvatelé: D'Alessio, A, Marchetti, M, Tartari, C, Russo, L, Cecchini, S, Lambregts, K, di Mauro, D, Falanga, A
Rok vydání: 2017
Předmět:
Male
Cancer Research
Time Factors
030204 cardiovascular system & hematology
LMWH
Thrombin generation
Gastroenterology
0302 clinical medicine
Neoplasms
Medicine
Prospective Studies
Cancer
Aged
80 and over
Thrombin
Venous Thromboembolism
General Medicine
Heparin
Middle Aged
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Female
medicine.drug
Adult
medicine.medical_specialty
medicine.drug_class
Down-Regulation
Low molecular weight heparin
Thrombin generation
Drug Administration Schedule
Fibrin Fibrinogen Degradation Products
Intestinal Hemorrhage
03 medical and health sciences
Deep vein thrombosi
Internal medicine
D-dimer
Humans
In patient
cardiovascular diseases
Blood Coagulation
Aged
business.industry
Anticoagulants
Heparin
Low-Molecular-Weight
medicine.disease
Surgery
Case-Control Studies
business
Venous thromboembolism
Biomarkers
Zdroj: Cancer Investigation. 35:490-499
ISSN: 1532-4192
0735-7907
DOI: 10.1080/07357907.2017.1340480
Popis: We enrolled 62 consecutive patients with advanced stage cancers and venous thromboembolism (VTE), prospectively followed until 1 year. All patients received 6 month low-molecular-weight heparin (LMWH) therapy. We evaluated thrombin generation (TG) and D-dimer levels at different time points, to determine whether they were sensitive to LMWH and explore a possible association with VTE recurrence, bleeding, and overall survival. During LMWH, levels of TG and D-dimer significantly dropped. No VTE recurrences occurred, one patient had cancer-related intestinal hemorrhage. LMWH treatment was effective in controlling patient hypercoagulation. No VTE recurrences were detected. High D-dimer concentration was an independent predictor of poor survival.
Databáze: OpenAIRE
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