Tumor Infiltrating Lymphocytes Affect the Outcome of Patients with Operable Triple-Negative Breast Cancer in Combination with Mutated Amino Acid Classes
| Autor: | Paris Kosmidis, Amanda Psyrri, Irene Nicolaou, Gerasimos Aravantinos, Flora Zagouri, George Pentheroudakis, Zoi Alexopoulou, Sotiris Lakis, Christos Papadimitriou, Evangelia Razis, Ioannis Efstratiou, George Fountzilas, Vassiliki Kotoula, Eleni Giannoulatou, Ioannis S. Vlachos, Dimitrios Pectasides, Kyriakos Chatzopoulos, Kyriaki Papadopoulou, Pavlos Papakostas, Maria Sotiropoulou, Helen Gogas |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Treatment lcsh:Medicine medicine.disease_cause 0302 clinical medicine Breast Tumors Basic Cancer Research Medicine and Health Sciences Medicine Stromal tumor lcsh:Science Immune Response Triple-negative breast cancer Mutation Multidisciplinary hemic and immune systems Nonsense Mutation Genomics Phenotype Oncology 030220 oncology & carcinogenesis Amino Acid Analysis Anatomy Research Article Histology Concordance Nonsense mutation Immunology chemical and pharmacologic phenomena Research and Analysis Methods 03 medical and health sciences Breast cancer Cancer Genomics Genomic Medicine Breast Cancer Genetics Molecular Biology Techniques Molecular Biology Molecular Biology Assays and Analysis Techniques business.industry Tumor-infiltrating lymphocytes lcsh:R Biology and Life Sciences Cancers and Neoplasms medicine.disease 030104 developmental biology Cancer research lcsh:Q business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 9, p e0163138 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Background Stromal tumor infiltrating lymphocytes (TILs) density is an outcome predictor in triple-negative breast cancer (TNBC). Herein we asked whether TILs are related to coding mutation load and to the chemical class of the resulting mutated amino acids, i.e., charged, polar, and hydrophobic mutations. Methods We examined paraffin tumors from TNBC patients who had been treated with adjuvant chemotherapy mostly within clinical trials (training cohort, N = 133; validation, N = 190) for phenotype concordance; TILs density; mutation load and types. Results Concordance of TNBC phenotypes was 42.1% upon local / central, and 72% upon central / central pathology assessment. TILs were not associated with mutation load, type and class of mutated amino acids. Polar and charged mutation patterns differed between TP53 and PIK3CA (p50% TILs tumors (training p = 0.003; validation p = 0.015). Conclusions TILs density is unrelated to mutation load in TNBC, which may be regarded as an unstable phenotype. If further validated, hydrophobic mutations along with TILs density may help identifying TNBC patients in higher risk for relapse. |
| Databáze: | OpenAIRE |
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