Serum antigliadin antibody levels as a screening criterion before jejunal biopsy indication for celiac disease in a developing country

Autor: A. Rabello, G. Brasileiro Filho, Magda Bahia, Francisco José Penna
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Male
Physiology
Biopsy
antigliadin antibodies
Disease
Biochemistry
Gastroenterology
Intestinal malabsorption
Medicine
General Pharmacology
Toxicology and Pharmaceutics
Child
lcsh:QH301-705.5
lcsh:R5-920
biology
General Neuroscience
General Medicine
Predictive value
Jejunum
Child
Preschool
Female
Antibody
lcsh:Medicine (General)
enteropathies
medicine.medical_specialty
Immunology
Biophysics
Antibody level
Enzyme-Linked Immunosorbent Assay
Sensitivity and Specificity
Statistics
Nonparametric
Predictive Value of Tests
Internal medicine
Humans
Jejunal biopsy
In patient
Developing Countries
Autoantibodies
Analysis of Variance
business.industry
Infant
Mean age
Cell Biology
Immunoglobulin A
Intestinal Diseases
lcsh:Biology (General)
Case-Control Studies
Immunoglobulin G
biology.protein
business
Biomarkers
celiac disease
Zdroj: Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 11, Pages: 1415-1420, Published: NOV 2001
Brazilian Journal of Medical and Biological Research, Vol 34, Iss 11, Pp 1415-1420 (2001)
Brazilian Journal of Medical and Biological Research v.34 n.11 2001
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Popis: The objective of the present study was to determine the efficacy of detection of antigliadin immunoglobulins G and A (IgG and IgA) for the diagnosis of celiac disease in a developing country, since other enteropathies might alter the levels of these antibodies. Three groups were studied: 22 patients with celiac disease (mean age: 30.6 months), 61 patients with other enteropathies (mean age: 43.3 months), and 46 patients without enteropathies (mean age: 96.9 months). Antigliadin IgG and IgA ELISA showed sensitivity of 90.9 and 95.5%, respectively. With the hypothetical values of prevalence ranging from 1:500 to 1:2000 liveborns, the positive predictive value varied from 8.5 to 2.3% for IgG and from 4.8 to 1.1% for IgA. Considering the patients without enteropathies, specificity was 97.8 and 95.7% for IgG and IgA, respectively. In patients with other enteropathies, specificity was 82.0 and 84.1%, respectively. When patients with and without other enteropathies were considered as a whole, specificity was 88.8 and 91.6%, respectively. The specificity of positive IgG or IgA was 93.5% in children without enteropathies and 78.7% in the presence of other enteropathies. The negative predictive value for hypothetical prevalences varying from 1:500 to 1:2000 liveborns was 99.9%. Thus, even in developing countries where the prevalence of non-celiac enteropathies is high, the determination of serum antigliadin antibody levels is a useful screening test prior to the jejunal biopsy in the investigation of intestinal malabsorption.
Databáze: OpenAIRE
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