| Autor: |
Muhammad Imran, Luping Zhang, Bohan Zheng, Zikai Zhao, Dengyuan Zhou, Shengfeng Wan, Zheng Chen, Hongyu Duan, Qiuyan Li, Xueqin Liu, Shengbo Cao, Shaoyong Ke, Jing Ye |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Virologica Sinica. 37:94-106 |
| ISSN: |
1995-820X |
| Popis: |
Flaviviruses are important arthropod-borne pathogens that represent an immense global health problem. Their unprecedented epidemic rate and unpredictable clinical features underscore an urgent need for antiviral interventions. Dehydroepiandrosterone (DHEA) is a natural occurring adrenal-derived steroid in the human body that has been associated in protection against various infections. In the present study, the plaque assay based primary screening was conducted on 32 synthetic derivatives of DHEA against Japanese encephalitis virus (JEV) to identify potent anti-flaviviral compounds. Based on primary screening, HAAS-AV3026 and HAAS-AV3027 were selected as hits from DHEA derivatives that exhibited strong antiviral activity against JEV (IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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