Green Strategy to Develop Novel Drug-Containing Poly (ε-Caprolactone)-Chitosan-Silica Xerogel Hybrid Fibers for Biomedical Applications

Autor:	Yi-Bo Zhou, Haisheng Qian, Hua-Jian Zhou, Shu-Hua Teng
Rok vydání:	2020
Předmět:	Materials science Article Subject Bioceramic Chitosan Solvent chemistry.chemical_compound Tetracycline Hydrochloride Chemical engineering chemistry T1-995 General Materials Science Thermal stability Drug carrier Hybrid material Caprolactone Technology (General)
Zdroj:	Journal of Nanomaterials, Vol 2020 (2020)
ISSN:	1687-4129 1687-4110
DOI:	10.1155/2020/6659287
Popis:	A facile and green method was explored to prepare the tetracycline hydrochloride- (TCH-) loaded poly (ε-caprolactone)-chitosan-silica xerogel (PCL-CS-SiO2) hybrid fibers by using 90% acetic acid as a suitable solvent. The SEM results showed that those fibers exhibited a continuous, bead-free morphology, an average diameter of about 430 nm, and super-hydrophilicity ( θ water ≈ 0 ° ). The presence of SiO2 was found to enhance the thermal stability of the hybrid fibers, and the actual content of SiO2 was obtained by the TG measurement. Moreover, SiO2 xerogel as an important bioceramic endowed the hybrid fibers with good drug release behavior and in vitro bioactivity, suggesting their potential use as novel drug carriers for bone tissue engineering. The present work is expected to offer a green strategy to develop novel, multifunctional hybrid materials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ce7ce349810db7613b9ccc773d5fd5 https://doi.org/10.1155/2020/6659287 Zobrazit plný text záznamu Plný text