Activity of nitric oxide synthase and concentration of nitric oxide end metabolites in the gingiva under experimental pathological conditions
| Autor: | I. A. Fil'chukova, V. L. Popkov, A. S. Dukhanin, V. P. Galenko-Yaroshevskii, N. V. Lapina |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Nitric Oxide Synthase Type III Gingiva Nitric Oxide Synthase Type II Nitric Oxide General Biochemistry Genetics and Molecular Biology Antioxidants Nitric oxide chemistry.chemical_compound Nitrate Internal medicine medicine Animals Nitrite Periodontitis Pathological biology General Medicine Metabolism medicine.disease Rats Nitric oxide synthase Oxidative Stress Endocrinology chemistry Picolines biology.protein Experimental pathology |
| Zdroj: | Bulletin of experimental biology and medicine. 140(4) |
| ISSN: | 0007-4888 |
| Popis: | Parameters of NO metabolism in the gingiva were studied during experimental periodontitis accompanied by alloxan diabetes and exogenous hypercholesterolemia. We measured activities of inducible and constitutive NO synthase and concentrations of stable NO end metabolites in rat gingival tissue (total contents of nitrite and nitrate). Under pathological conditions NO metabolism significantly differed from the control. Treatment with mexidol for 14 days significantly decreased activity of inducible NO synthase in the gingiva of experimental animals. |
| Databáze: | OpenAIRE |
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