Human Herpesvirus 8 Oral Shedding in HIV-Infected Men With and Without Kaposi Sarcoma
| Autor: | Michele Baumann, Peter Itin, Rainer Weber, Isabelle C Widmer, Heini Grob, Aline Stalder, Gieri Cathomas, Peter Erb |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Herpesvirus 4 Human viruses HIV Infections medicine.disease_cause Herpesviridae Men who have sex with men Serology Acquired immunodeficiency syndrome (AIDS) Immunopathology medicine Humans Gammaherpesvirinae Pharmacology (medical) Oral mucosa Viral shedding Sarcoma Kaposi biology Mouth Mucosa virus diseases Middle Aged biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease CD4 Lymphocyte Count Virus Shedding Infectious Diseases medicine.anatomical_structure Herpesvirus 8 Human Immunology |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 42:420-425 |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/01.qai.0000226790.31463.e6 |
| Popis: | Objectives: Two main routes of human herpesvirus 8 (HHV-8) transmission are known: sexual, predominantly in men who have sex with men; and nonsexual, in endemic populations. Both routes implicate saliva, so identifying the factors that influence oral HHV-8 shedding is important. Methods: Using polymerase chain reaction and immunohistochemistry, we prospectively analyzed HHV-8 infection of oral epithelial cells in 98 Swiss HIV Cohort Study patients, with mean follow-up of 9.4 years, and correlated data to immune status, HHV-8 serology, and Kaposi sarcoma (KS) history, as well as survival. Results: Sixty-eight (43.9%) of the 98 men were HHV-8 seropositive, and 33 (33.67%) had a history of KS. In both groups, men who have sex with men were significantly more affected than heterosexuals (P < 0.05). Of 77 patients, 9 (11.6%) were oral HHV-8 polymerase chain reaction positive, and 2 of these were also positive by immunohistochemistry. Oral HHV-8 detection was not influenced by the immune status, but a trend toward higher detection was observed in patients with KS (P = 0.084). Oral HHV-8 shedding had no predictive value either for the development of KS lesions or for survival. Conclusions: Human herpesvirus 8 can be present in oral epithelial cells and is shed independent of the patient's immune status, indicating that oral HHV-8 shedding may occur at any time in HHV-8-seropositive individuals. |
| Databáze: | OpenAIRE |
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