Association of genetic variations in the serotonin and dopamine systems with aggressive behavior in the Chinese adolescent population: Single- and multiple-risk genetic variants
| Autor: | Qiuge Yan, Hongjuan Chang, Xiaozhou Ye, Chunxia Wu, Juan Huang, Yizhen Yu, Lina Tang, Linguo Wu, Yuqiao Ma |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Oncology Cart China Serotonin medicine.medical_specialty Candidate gene Adolescent Genotyping Techniques Dopamine Single-nucleotide polymorphism Biology Logistic regression Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Surveys and Questionnaires Internal medicine Genetic variation Genotype medicine Genetic predisposition Humans Genetic Predisposition to Disease Genetics Aggression Receptors Dopamine D4 Receptors Dopamine D3 Nuclear Proteins DNA-Binding Proteins Psychiatry and Mental health Clinical Psychology 030104 developmental biology Adolescent Behavior medicine.symptom 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Journal of Affective Disorders. 225:374-380 |
| ISSN: | 0165-0327 1685-9448 |
| DOI: | 10.1016/j.jad.2017.08.052 |
| Popis: | Background Genetic predisposition is an important factor leading to aggressive behavior. However, the relationship between genetic polymorphisms and aggressive behavior has not been elucidated. Methods We identified candidate genes located in the dopaminergic and serotonin system (DRD3, DRD4, and FEV) that had been previously reported to be associated with aggressive behavior. We investigated 14 tag single-nucleotide polymorphisms (SNPs) using a multi-analytic strategy combining logistic regression (LR) and classification and regression tree (CART) to explore higher-order interactions between these SNPs and aggressive behavior in 318 patients and 558 controls. Results Both LR and CART analyses suggested that the rs16859448 polymorphism is the strongest individual factor associated with aggressive behavior risk. In CART analysis, individuals carrying the combined genotypes of rs16859448TT/GT-rs11246228CT/TT-rs3773679TT had the highest risk, while rs16859448GG-rs2134655CT had the lowest risk (OR = 5.25, 95% CI: 2.53–10.86). Conclusion This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents. However, the aggressive behavior scale used to diagnose aggression in this study did not account for comorbid conditions; therefore, further studies are needed to confirm our observations. |
| Databáze: | OpenAIRE |
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