Mixed vitamin C and zinc diet supplements co-administered with artemether drug improved haematological profile and survival of mice infected with Plasmodium berghei
| Autor: | Nkiru Esther Ekechukwu, Chimdinma F. Chukwuma, Chike Ebido, Ifeanyi Oscar Aguzie, Felicia Nkechi Ekeh, Stanley Ndubuisi Oluah, Chinenye Maria-Goretti Ohanu |
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| Rok vydání: | 2019 |
| Předmět: |
030309 nutrition & dietetics
Physiology chemistry.chemical_element lcsh:TX341-641 Zinc 03 medical and health sciences 0404 agricultural biotechnology White blood cell medicine Plasmodium berghei Artemether 0303 health sciences biology Vitamin C business.industry Mortality rate Therapeutic effect 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 040401 food science medicine.anatomical_structure chemistry business lcsh:Nutrition. Foods and food supply Malaria Food Science medicine.drug |
| Zdroj: | Food Science and Human Wellness, Vol 8, Iss 3, Pp 275-282 (2019) |
| ISSN: | 2213-4530 |
| DOI: | 10.1016/j.fshw.2019.05.003 |
| Popis: | Iron and zinc deficiencies is common in malaria endemic areas and contributes to morbidity. Vitamin C and zinc combined supplements have been hypothesized as a remedy. This study evaluated the effect of different combinations of vitamin C and zinc on haematological parameters and mortality of Plasmodium berghei-infected mice (Mus musculus). A three-week trial was carried out to assess haematological changes and mortality of mice after 3-day artemether treatment co-administered with vitamin C - zinc supplements. Grouping was based on combinations of vitamin C and zinc. Weight, packed cell volume (PCV), white blood cell count (WBC), red blood cell count (RBC), haemoglobin concentration (HB), and mortality were assayed weekly. The supplement improved PCV, HB, mean cell volume (MCV) and mean cell haemoglobin (MCH). Mice mortality was higher in the absence of the supplement, though the difference was not significant (χ2 = 5.214, P = 0.5167). Parasitaemia was not reduced by the supplement. A 30:70 vitamin C - zinc supplement performed better than other combinations used. Therefore, vitamin C - zinc supplement play roles in the management of malaria, since they improved PCV and HB, and lowered mortality rate, complementing the therapeutic effect of artemether. Keywords: Dietary supplement, Food supplement, Micronutrient, Zinc, Vitamin C, Malaria, Nutritional medicine |
| Databáze: | OpenAIRE |
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