Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy
Autor: | Christoph Fehr, Alexandra Schleicher, I. O. N. Anghelescu, Armin Szegedi, Christoph Klawe, Christoph Hiemke, Norbert Dahmen |
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Rok vydání: | 2001 |
Předmět: |
Adult
Male medicine.medical_specialty Generalized anxiety disorder Genotype Neurological disorder Tryptophan Hydroxylase Polymerase Chain Reaction Internal medicine medicine Humans Receptor Serotonin 5-HT2A Biological Psychiatry Psychiatric genetics Alleles Narcolepsy Pharmacology Sleep disorder Polymorphism Genetic Panic disorder Alcohol dependence Middle Aged medicine.disease Anxiety Disorders Alcoholism Endocrinology Receptors Serotonin Anxiety Female medicine.symptom Psychology |
Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 25(5) |
ISSN: | 0278-5846 |
Popis: | 1. Alterations in the serotonergic neurotransmission have been frequently described for patients suffering from alcoholism, anxiety disorders and narcolepsy. 2. The authors tested for association of the 5-HT2A receptor polymorphism (T102C) and the intron 7 tryptophan hydroxylase (TPH) polymorphism (A218C) among 176 alcohol dependent patients, 35 patients with panic disorder, 50 patients with generalized anxiety disorder, 55 patients with narcolepsy and 87 healthy controls. 3. Allele and genotype frequencies of the 5-HT2A receptor polymorphism (T102C), the intron 7 TPH polymorphism (A218C) were almost similar between the patients suffering from alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy 4. There was no association between the 5-HT2A receptor polymorphism (T102C), the intron 7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of German patients. |
Databáze: | OpenAIRE |
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