OLIGONUCLEOTIDES WITH ISOPOLAR PHOSPHONATE INTERNUCLEOTIDE LINKAGE: A NEW PERSPECTIVE FOR ANTISENSE COMPOUNDS?

Autor:	Pavol Kois, Jan Snášel, Šárka Králíková, Ivan Rosenberg, Markéta Rinnová, Ondřej Pačes, Radek Liboska, Dominik Rejman, Zdeněk Točík
Rok vydání:	2001
Předmět:	Thymidine monophosphate biology Oligonucleotide Chemistry Stereochemistry Ribonuclease H Organophosphonates Nucleic Acid Hybridization General Medicine Oligonucleotides Antisense Biochemistry Phosphonate Adenosine Monophosphate RNase H activity Nucleic acid thermodynamics chemistry.chemical_compound Cross-Linking Reagents Antisense oligonucleotides Thymidine Monophosphate Genetics biology.protein Molecular Medicine RNase H
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 20:819-823
ISSN:	1532-2335 1525-7770
DOI:	10.1081/ncn-100002437
Popis:	Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c8b796d170b68d91c6d66bf03441e3 https://doi.org/10.1081/ncn-100002437 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.