OptimisAtion of Diagnostic Accuracy in idioPathic inflammaTory myopathies (ADAPT study): A protocol for a prospective diagnostic accuracy study of multimodality testing in patients suspected of a treatable idiopathic inflammatory myopathy

Autor: Hannah A W Walter, Renske G Kamperman, Joost Raaphorst, Camiel Verhamme, Johannes H T M Koelman, Wouter V Potters, Robert Hemke, Frank F Smithuis, Eleonora Aronica, Ester M M van Leeuwen, Paul A Baars, Marianne de Visser, Ivo N van Schaik, Patrick M M Bossuyt, Anneke J van der Kooi
Přispěvatelé: Radiology and nuclear medicine, Pathology, Neurology, ANS - Neurodegeneration, ANS - Neuroinfection & -inflammation, AII - Inflammatory diseases, Radiology and Nuclear Medicine, AMS - Musculoskeletal Health, AMS - Sports, Graduate School, ANS - Cellular & Molecular Mechanisms, Experimental Immunology, AII - Infectious diseases, Epidemiology and Data Science, APH - Methodology, APH - Personalized Medicine, EURO-NMD
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMJ Open, 11(12):e053594. BMJ Publishing Group
Walter, H A W, Kamperman, R G, Raaphorst, J, Verhamme, C, Koelman, J H T M, Potters, W V, Hemke, R, Smithuis, F F, Aronica, E, van Leeuwen, E M M, Baars, P A, de Visser, M, van Schaik, I N, Bossuyt, P M M & van der Kooi, A J 2021, ' OptimisAtion of Diagnostic Accuracy in idioPathic inflammaTory myopathies (ADAPT study) : A protocol for a prospective diagnostic accuracy study of multimodality testing in patients suspected of a treatable idiopathic inflammatory myopathy ', BMJ Open, vol. 11, no. 12, e053594 . https://doi.org/10.1136/bmjopen-2021-053594
BMJ Open
BMJ open, 11(12):e053594. BMJ Publishing Group
ISSN: 2044-6055
Popis: IntroductionIdiopathic inflammatory myopathies (IIMs) excluding inclusion body myositis (IBM) are a group of heterogeneous autoimmune disorders characterised by subacute-onset and progressive proximal muscle weakness, which are frequently part of a multisystem autoimmune disorder. Reaching the diagnosis can be challenging, and no gold standard for the diagnosis of IIM exists. Diagnostic modalities include serum creatine kinase activity, muscle imaging (MRI or ultrasound (US)), electromyography (EMG), myositis autoantibody testing and muscle biopsy. Several diagnostic criteria have been developed for IIMs, varying in reported sensitivity and specificity.HypothesisWe hypothesise that an evidence-based diagnostic strategy, using fewer and preferably the least invasive diagnostic modalities, can achieve the accuracy of a complete panel of diagnostic tests, including MRI, US, EMG, myositis-specific autoantibody testing and muscle biopsy.Methods and analysisThe OptimizAtion of Diagnostic Accuracy in idioPathic inflammaTory myopathies study is a prospective diagnostic accuracy study with an over-complete study design. 100 patients suspected of an IIM excluding IBM will be included. A reference diagnosis will be assigned by an expert panel using all clinical information and all results of all ancillary tests available, including 6 months of follow-up. Several predefined diagnostic strategies will be compared against the reference diagnosis to find the optimal diagnostic strategy.Ethics and disseminationEthical approval was obtained from the medical ethics committee of the Academic Medical Centre, University of Amsterdam, The Netherlands (2019-814). The results will be distributed through conference presentations and peer-reviewed publications.Trial registration numberNetherlands trial register; NL8764.
Databáze: OpenAIRE
Externí odkaz: