Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
| Autor: | Aida Iraji, Anahita Boveiri Dehsheikh, Kamiar Zomorodian, Javad Mottaghipisheh, Hadi Taghrir, Cambyz Irajie, Mohammad Mahmoodi Sourestani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Scrophulariaceae bioactivities media_common.quotation_subject Flavonoid Pharmaceutical Science Review Micromeria Pharmacy and materia medica Drug Discovery Buddleja media_common chemistry.chemical_classification biology Traditional medicine linarin Glycoside biology.organism_classification RS1-441 chemotaxonomy chemistry Phytochemical flavonoids Molecular Medicine Medicine phytochemistry Lamiaceae |
| Zdroj: | Pharmaceuticals Pharmaceuticals, Vol 14, Iss 1104, p 1104 (2021) |
| ISSN: | 1424-8247 |
| Popis: | Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the Cirsium, Micromeria, and Buddleja species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |