Evolution of the human chromosome 13 synteny: Evolutionary rearrangements, plasticity, human disease genes and cancer breakpoints
| Autor: | Polina L. Perelman, Vanessa Milioto, Natalia A. Serdyukova, Rita Scardino, Anastasia A. Proskuryakova, Francesca Dumas |
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| Přispěvatelé: | Scardino R., Milioto V., Proskuryakova A.A., Serdyukova N.A., Perelman P.L., Dumas F. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Chromosomes Artificial Bacterial lcsh:QH426-470 Plasticity Evolution Context (language use) Biology BAC probe Settore BIO/08 - Antropologia Synteny 010603 evolutionary biology 01 natural sciences Genome Article Evolution Molecular 03 medical and health sciences Painting BAC probes FISH Neoplasms Genetics Animals Humans Phylogeny Genetics (clinical) Chromosome 13 Gene Rearrangement Mammals Bacterial artificial chromosome Autosome Chromosomes Human Pair 13 Chromosome Mapping Chromosome Karyotype lcsh:Genetics 030104 developmental biology Evolutionary biology Human synteny |
| Zdroj: | Genes Volume 11 Issue 4 Genes, Vol 11, Iss 383, p 383 (2020) |
| Popis: | The history of each human chromosome can be studied through comparative cytogenetic approaches in mammals which permit the identification of human chromosomal homologies and rearrangements between species. Comparative banding, chromosome painting, Bacterial Artificial Chromosome (BAC) mapping and genome data permit researchers to formulate hypotheses about ancestral chromosome forms. Human chromosome 13 has been previously shown to be conserved as a single syntenic element in the Ancestral Primate Karyotype in this context, in order to study and verify the conservation of primate chromosomes homologous to human chromosome 13, we mapped a selected set of BAC probes in three platyrrhine species, characterised by a high level of rearrangements, using fluorescence in situ hybridisation (FISH). Our mapping data on Saguinus oedipus, Callithrix argentata and Alouatta belzebul provide insight into synteny of human chromosome 13 evolution in a comparative perspective among primate species, showing rearrangements across taxa. Furthermore, in a wider perspective, we have revised previous cytogenomic literature data on chromosome 13 evolution in eutherian mammals, showing a complex origin of the eutherian mammal ancestral karyotype which has still not been completely clarified. Moreover, we analysed biomedical aspects (the OMIM and Mitelman databases) regarding human chromosome 13, showing that this autosome is characterised by a certain level of plasticity that has been implicated in many human cancers and diseases. |
| Databáze: | OpenAIRE |
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