The effect of I.V. L-NG Methylarginine Hydrochloride (L-NMMA: 546C88) on Basal and Acetazolamide (Diamox®) induced Changes of Blood Velocity in Cerebral Arteries and Regional Cerebral Blood flow in Man
| Autor: | Allan R. Andersen, Jes Olesen, LH Lassen, B Sperling |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Methylarginine Cerebral arteries 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.artery medicine Humans Drug Interactions Infusions Intravenous Cross-Over Studies omega-N-Methylarginine business.industry General Medicine Cerebral Arteries Crossover study nervous system diseases Transcranial Doppler Acetazolamide chemistry Cerebral blood flow Regional Blood Flow Cerebrovascular Circulation Anesthesia Middle cerebral artery cardiovascular system Omega-N-Methylarginine Female Neurology (clinical) business Blood Flow Velocity 030217 neurology & neurosurgery circulatory and respiratory physiology medicine.drug |
| Zdroj: | Cephalalgia. 25:344-352 |
| ISSN: | 1468-2982 0333-1024 |
| DOI: | 10.1111/j.1468-2982.2004.00862.x |
| Popis: | The aim of this study was to estimate the effect of Nitric Oxide synthase (NOS)-inhibition (L-NMMA) on the diameter of the middle cerebral artery (MCA) and on regional cerebral blood flow (rCBF). Furthermore, to assess the effect of L-NMMA on acetazolamide induced increases in MCA blood velocity (Vmean) and rCBF. In an open crossover design 12 healthy subjects attended the laboratory twice. The first day 6 mg/kg L-LNMMA i.v. over 15 min preceded 1 g acetazolamide iv over 5 min. Eight days later only acetazolamide was given. Vmean in MCA was determined with transcranial Doppler (TCD) and rCBF with Xe-133 inhalation SPECT at baseline, after L-NMMA and 25 and 55 min after acetazolamide infusion. After L-NMMA the decrease in rCBFMCA was 6.8% (± 7.4) ( P < 0.019, n = 12), whereas Vmean was not affected ( P = 0.83, n = 8). The change in MCA diameter was estimated to -1.3% ( P = 0.44, n = 8). L-NMMA did not affect acetazolamide increases in Vmean ( P = 0.67, n = 8) nor rCBF ( P = 0.29, n = 12). The percentage increase of Vmean was 1.5 times that of rCBF ( n = 8). Our data suggest that the basal tone of human cerebral arterioles but not of conduit arteries is NO-dependent. The action of acetazolamide in man is not NO-dependent. |
| Databáze: | OpenAIRE |
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