Effect of nitric oxide synthase inhibitors in acute lung injury due to blunt lung trauma in rats
| Autor: | Kürşat Yildiz, Cuneyt Ozer, Aykut Eliçora, Deniz Sahin, Uğur Temel, Asli Gül Akgül, Ozgur Doga Ozsoy, Salih Topçu, Hale Maral Kir, Meltem Ozlen Dillioglugil |
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| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Lung biology business.industry Lung injury Pharmacology Malondialdehyde medicine.disease Nitric oxide Superoxide dismutase Lipid peroxidation Pulmonary contusion Nitric oxide synthase chemistry.chemical_compound trauma medicine.anatomical_structure chemistry Acute lung injury medicine biology.protein oxidative stress Original Article Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Turkish Journal of Thoracic and Cardiovascular Surgery. 27:63-72 |
| ISSN: | 2149-8156 1301-5680 |
| Popis: | WOS: 000455260600010 Background: This study aims to investigate the effects of blunt lung trauma performed in experimental rat model on lung tissue and blood as well as proinflammatory cytokines, oxidant-antioxidant enzymes and histopathological parameters after Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine administration. Methods: The study included 50 adult male Wistar albino rats (weighing 350 to 400 g). Rats were randomly allocated into four groups. Except in the control, moderate-level pulmonary contusion was created in all other groups. Intraperitoneal saline solution was performed in groups 1 and 2, 25 mg.kg(-1) Ngamma-nitro-L-arginine methyl ester in group 3, and 20 mg. kg(-1) N-iminoethyl-L-ornithine in group 4. Blood and lung tissues were studied biochemically and histopathologically. Results: Best outcomes were recorded statistically significantly in groups with administration of Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine when malondialdehyde response, mucous and histopathological values were examined. Significant improvement was detected in superoxide dismutase values in the group with administration of competitive nitric oxide synthase inhibitor Ngamma-nitro-L-arginine methyl ester. Nitric oxide values were substantially decreased in N-iminoethyl-L-ornithine group, while no significance was detected. Conclusion: Free oxygen radicals and lipid peroxidation played a role in pulmonary contusion after blunt lung trauma. According to biochemical and histopathological outcomes, effects of inflammation were decreased and protective effects were formed with administration of both Ngammanitro-L-arginine methyl ester and N-iminoethyl-L-ornithine. |
| Databáze: | OpenAIRE |
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