Brachial artery flow-mediated dilatation and carotid intima-media thickness in young ED patients with insulin resistance
| Autor: | Fufu Zheng, Chunhua Deng, Sheng-Fu Chen, Xiangzhou Sun, Qiyun Yang, Fengjuan Yao, Xie Mq, Ding M, Yan-Ping Huang, Rongpei Wu, Ya-Dong Zhang, Da-Yu Han, Guihua Liu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Brachial Artery Urology 030232 urology & nephrology 030204 cardiovascular system & hematology Asymptomatic Carotid Intima-Media Thickness 03 medical and health sciences Young Adult 0302 clinical medicine Insulin resistance Erectile Dysfunction Internal medicine medicine.artery medicine Humans Insulin Testosterone cardiovascular diseases Brachial artery Subclinical infection Ultrasonography Doppler Duplex business.industry medicine.disease Prolactin Endocrinology Erectile dysfunction Intima-media thickness cardiovascular system Cardiology medicine.symptom Peyronie's disease Insulin Resistance business |
| Zdroj: | International journal of impotence research. 28(5) |
| ISSN: | 1476-5489 |
| Popis: | The evidence of a close relationship between cardiovascular disease and erectile dysfunction (ED) is well documented. The aim of this study is to investigate whether there is an early asymptomatic impairment of the peripheral vasculature in young ED patients without obvious cardiovascular disease. We studied a total of 261 ED patients (19–40 years old) and 40 age-matched healthy controls. All participants received questionnaires of cardiovascular risk factors and erectile function assessment, were subjected to lab tests of fasting blood sample, and underwent the ultrasonographic examination of brachial artery flow-mediated dilation (FMD) and carotid intima-media thickness (c-IMT). Insulin resistance (IR) was measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Compared with normal human controls, FMD was significantly lower, whereas the average c-IMT was significantly greater in ED patients. An inverse correlation was found between FMD and mean c-IMT. The ED patients had significantly higher levels of fasting glucose, fasting insulin and HOMA-IR index, but showed relatively lower total testosterone and prolactin levels than the controls. Both FMD and c-IMT showed a significant correlation with International Index of Erectile Function-5 questionnaire (IIEF-5) score, age and HOMA-IR. Multivariate stepwise regression analysis demonstrated that age, HOMA-IR and IIEF-5 score were the risk factors associated with FMD and c-IMT. In conclusion, young ED patients in association with IR display diminished FMD and increased c-IMT. Furthermore, ED, HOMA-IR and age are independent predictors of the two subclinical atherosclerotic markers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|