Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor

Autor: Bart van de Sluis, Linda van Genne, Hongjuan Yu, Wellington M Candido, Hasan Mahmud, Rudolf A. de Boer, Jan M. van Deursen, Wiek H. van Gilst, Herman H W Silljé, Inge Vreeswijk-Baudoin
Přispěvatelé: Center for Liver, Digestive and Metabolic Diseases (CLDM), Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
Rok vydání: 2014
Předmět:
Male
Anatomy and Physiology
Mouse
lcsh:Medicine
Blood Pressure
HUMAN (PRO)RENIN RECEPTOR
Cardiovascular
Cardiovascular System
Muscle hypertrophy
ACTIVATION
Fibrosis
BINDING
Prorenin Receptor
Hypoxia
lcsh:Science
Receptor
Creatine Kinase
Multidisciplinary
Heart
Animal Models
Echocardiography
Reperfusion Injury
TRANSGENIC RATS
Medicine
medicine.symptom
Genetic Engineering
Research Article
Biotechnology
Genetically modified mouse
Cardiac function curve
medicine.medical_specialty
Blotting
Western
Cardiomegaly
Mice
Transgenic
Receptors
Cell Surface
Biology
Real-Time Polymerase Chain Reaction
RENIN/PRORENIN RECEPTOR
Model Organisms
GLOMERULOSCLEROSIS
Internal medicine
medicine
Animals
Humans
Heart Failure
L-Lactate Dehydrogenase
HYPERTENSION
Myocardium
lcsh:R
Isoproterenol
Hypoxia (medical)
medicine.disease
HYPERTROPHY
MICE
Endocrinology
Gene Expression Regulation
CELLS
biology.protein
lcsh:Q
Creatine kinase
Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19]
Reperfusion injury
Transgenics
HeLa Cells
Zdroj: PLoS One, 9, 2
PLoS ONE, Vol 9, Iss 2, p e89929 (2014)
PLoS ONE, 9(2):e89929. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS One, 9
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0089929
Popis: Contains fulltext : 127542.pdf (Publisher’s version ) (Open Access) The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgenic mouse (Tg) with cardio-restricted (P)RR overexpression driven by the alpha-MHC promotor. The mRNA expression of (P)RR was approximately 170-fold higher (P
Databáze: OpenAIRE
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