Prognostic significance of clinical parameters and Epstein-Barr virus infection in non-endemic undifferentiated carcinoma of nasopharyngeal type: a Serbian report
| Autor: | I. P. Pendjer, Nada Tomanovic, Tatjana Terzic, M. I. Boricic, Dimitrije Brasanac, D. T. Ruzic Zecevic, Ivan Boricic |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Oncology Epstein-Barr Virus Infections Cancer Research medicine.medical_specialty Pathology Adolescent Population Kaplan-Meier Estimate Disease-Free Survival Young Adult hemic and lymphatic diseases Internal medicine medicine Humans Stage (cooking) education Epstein–Barr virus infection Survival rate In Situ Hybridization Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over education.field_of_study Nasopharyngeal Carcinoma Tissue microarray business.industry Incidence (epidemiology) Carcinoma Age Factors Cell Differentiation Nasopharyngeal Neoplasms Hematology General Medicine Middle Aged Prognosis medicine.disease Nasopharyngeal carcinoma Tissue Array Analysis Female business Serbia Chemoradiotherapy |
| Zdroj: | Medical Oncology. 28:1325-1330 |
| ISSN: | 1559-131X 1357-0560 |
| Popis: | Undifferentiated carcinoma of nasopharyngeal type (UCNT) is very rare tumour in Serbia, like in most of the countries of Europe, with incidence less than 0.5 per 100,000 people per year. The aim of this study was to assess the presence of Epstein-Barr virus (EBV) in the UCNT of a non-endemic population in Serbia and identify the main clinical parameters that interfere with patients' survival rate. This study included 102 patients with UCNT who were diagnosed between 1996 and 2003. Biopsies were analysed for EBV-encoded RNA (EBER) by in situ hybridization of tumour tissue microarray. Of 102 patients, 76 were men and 26 were women with ages ranging between 18 and 82 years (median 52.5, mean 53.0 ± 14.1). Survival rates were 80, 39 and 31% for one, three and five years, respectively. Ninety-three of 102 cases were EBER positive (92%). Factors with unfavourable prognostic values were age over 50 years at the time of diagnosis, advanced clinical stage, therapy other than chemoradiotherapy and EBER negative status. In regard to the clinical data, EBER expression in UCNT was shown to be a strong independent predictor of overall and progression-free survival. To our knowledge, the current report constitutes the largest European non-endemic series of UCNT samples from a single institution with correlation between survival and clinical parameters/EBER status. |
| Databáze: | OpenAIRE |
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