Treatment of Ulcerative Colitis with Camostat Mesilate, A Serine Protease Inhibitor
| Autor: | Shigeru Senda, Yoshihide Fujiyama, Tadao Bamba, Shiro Hosoda |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Camostat Proteases Serine Proteinase Inhibitors Gabexate Pharmacology Guanidines Inflammatory bowel disease chemistry.chemical_compound Internal Medicine medicine Humans Colitis Serine protease biology business.industry Esters General Medicine medicine.disease Ulcerative colitis chemistry Enzyme inhibitor Pancreatic juice Immunology biology.protein Colitis Ulcerative business |
| Zdroj: | Internal Medicine. 32:350-354 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | We were able to induce and maintain remission with camostat mesilate, a serine protease inhibitor, in two patients with ulcerative colitis, to whom salicylazosulfapyridine could not be administered due to previous side effects. The enzymatic activity of proteases from granulocyte, pancreatic juice and bacteria is possibly harmful to the inflamed colonic mucosa. Camostat mesilate can be expected to have an anti-inflammatory effect on the damaged mucosa of inflammatory bowel disease. |
| Databáze: | OpenAIRE |
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