Resveratrol attenuates behavioural impairment associated with learning and memory in rats with diabetes induced by a high‐fat diet and streptozotocin

Autor: SURENDRA BODAKHE, Dr. Amrita Singh
Rok vydání: 2022
Předmět:
Zdroj: British Journal of Pharmacology. 179:4673-4691
ISSN: 1476-5381
0007-1188
DOI: 10.1111/bph.15895
Popis: A high-fat diet (HFD) is a common risk factor for Type 2 diabetes mellitus (T2DM) and its associated cognitive impairments. In models of diabetes, resveratrol, a modulator of SIRT1, regulates the fasting glucose and antioxidant levels, as well as the lipid profile. Resveratrol may also alleviate the cognitive dysfunctions associated with diabetes.Albino rats were fed a HFD, (60% kcal fat) after treatment with streptozotocin (45 mg·kgTreatment with resveratrol attenuated the increased glucose levels (pre- and post-prandial), impaired glucose tolerance, HbA1c, and decreased the body weights of the T2DM rats. Moreover, resveratrol ameliorated the impaired learning and memory associated with increased SIRT1 and decreased TGF-β1, TNF-α, oxidative-nitroso-stress, and cholinergic activities in the plasma and the brains of the T2DM animals.Our results demonstrated that SIRT1 modulation interacted with TGF-β1 signalling, and mitigated hyperglycaemia and subsequent learning-memory impairments in the T2DM animals. Our study also suggested novel therapeutic targets, including TGF-β1, which may add to our knowledge of resveratrol, when used to treat impaired memory associated with diabetes.
Databáze: OpenAIRE
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