Helicobacter pylori in patients can be killed by visible light
| Autor: | Aamir Ahmad, M. Joshua Tolkoff, Jennifer Viveiros, Ayesha Khalil, Michael R. Hamblin, Robert A. Ganz, Atosa Ahmadi, Norman S. Nishioka |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Peptic Ulcer Endoscope Light medicine.drug_class medicine.medical_treatment Antibiotics Photodynamic therapy Pilot Projects Dermatology Gastroenterology Article Helicobacter Infections Internal medicine Gastroscopy medicine Gastric mucosa Pyloric Antrum Humans Single-Blind Method Prospective Studies Dyspepsia Aged Aged 80 and over biology Helicobacter pylori business.industry Middle Aged Phototherapy medicine.disease Antimicrobial biology.organism_classification medicine.anatomical_structure Gastric Mucosa Adenocarcinoma Surgery Female business |
| Zdroj: | Lasers in surgery and medicine. 36(4) |
| ISSN: | 0196-8092 |
| Popis: | Background Helicobacter pylori colonizes the mucus layer of the human stomach and may cause peptic ulcer and adenocarcinoma. Novel antimicrobial approaches are sought due to the occurrence of antibiotic resistance and consequent treatment failure. We report here that H. pylori is susceptible to inactivation by blue light. Study Design/Materials and Methods A controlled, prospective, blinded, trial of endoscopically delivered blue light to eradicate H. pylori in regions of the gastric antrum, in 10 patients between the ages of 21 and 80 who tested positive for H. pylori. Light (405 nm) (40 J/cm2) was delivered to a 1-cm diameter spot in the gastric antrum via optical fiber passed through the endoscope and weighed biopsies were taken from treated and control spots and colonies quantitatively cultured. Results Blue light killed 5 logs of bacteria in vitro. The mean reduction in H. pylori colonies per gram tissue between treated and control spots was 91% (7.4±4.8×106 vs. 8.1±1.9×107, two-tailed P |
| Databáze: | OpenAIRE |
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