Replication of hepatitis B in HBsAg-positive siblings
Autor: | Chien-Hung Chen, Ching-Shu Hung, Chia-Ming Chu, Dar-In Tai, Sing Kai Lo, Chung-Huang Kuo, Jeng-Ming Du |
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Rok vydání: | 2002 |
Předmět: |
Adult
Male Pediatrics medicine.medical_specialty HBsAg China Hepatitis B virus Carcinoma Hepatocellular Adolescent medicine.disease_cause Virus Replication Asymptomatic Nuclear Family Virology medicine Humans Hepatitis B e Antigens Prospective Studies Sibling Hepatitis B Surface Antigens Hepatology business.industry Sibling order Liver Neoplasms virus diseases Hepatitis B Middle Aged medicine.disease digestive system diseases Infectious Disease Transmission Vertical Infectious Diseases HBeAg Hepatocellular carcinoma Immunology Carrier State Female medicine.symptom business |
Zdroj: | Journal of viral hepatitis. 9(4) |
ISSN: | 1352-0504 |
Popis: | Persistent hepatitis B virus (HBV) replication is important for progression of chronic liver diseases. To understand whether there is a trend of HBV replication in siblings or not, 1850 relatives of patients with hepatocellular carcinoma (HCC) were examined prospectively for liver function test, viral markers and HBV DNA. The prevalence of HBsAg in the parents', siblings', children's and grandchildren's generations were 43.4%, 57.2%, 35.5% and 32.1%, respectively. The prevalence of hepatitis B e antigen (HBeAg) in sibling's generation (mean age 44.4 years) was 19%, which is higher than that of asymptomatic HBsAg carriers. For siblings in the children's generation, the prevalence of HBeAg in hepatitis B surface antigen (HBsAg) carriers declined from 40% in the eldest siblings to 19% in the youngest siblings. In 75 families clustered with three or more HBsAg carrier siblings, the mean age for seven families of which all siblings remained HBeAg + was younger, whereas the mean age for 35 families of which all siblings had cleared HBeAg was older. For the remaining 33 families, in only 10 families had the older siblings cleared the HBeAg earlier than the younger siblings. Twenty families showed that younger siblings cleared the HBeAg earlier than the older or middle siblings. We concluded that HBV replication in HCC relatives cannot be explained by familial tendency alone. A significant number of younger siblings appeared to have a shorter HBV replication phase than their older siblings. The possible role of this in maternal–fetal transmission is discussed. |
Databáze: | OpenAIRE |
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