Healing acceleration of acetic acid-induced colitis by marigold (Calendula officinalis) in male rats

Autor: Sajad Daneshi, Mozhdeh Raam, Masood Hosseinzadeh, Akram Jamshidzadeh, Seyedeh-Leili Asadi-Yousefabad, Masood Sepehrimanesh, Nader Tanideh, Omid Koohi-Hosseinabadi, Asma Najibi
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Pathology
medicine.medical_specialty
040301 veterinary sciences
medicine.medical_treatment
Administration
Oral
Histopathology
Enema
Pharmacology
Inflammatory bowel disease
0403 veterinary science
Intracolonic
03 medical and health sciences
chemistry.chemical_compound
Random Allocation
0302 clinical medicine
Calendula
medicine
Animals
oxidative stress
Colitis
lcsh:RC799-869
Acetic Acid
ulcerative colitis
biology
business.industry
Plant Extracts
Body Weight
Gastroenterology
04 agricultural and veterinary sciences
medicine.disease
Malondialdehyde
biology.organism_classification
Rats
Disease Models
Animal
Treatment Outcome
chemistry
Calendula officinalis
030220 oncology & carcinogenesis
Myeloperoxidase
Officinalis
biology.protein
Original Article
Colitis
Ulcerative
lcsh:Diseases of the digestive system. Gastroenterology
marigold
business
Phytotherapy
Zdroj: The Saudi Journal of Gastroenterology, Vol 22, Iss 1, Pp 50-56 (2016)
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
ISSN: 1998-4049
1319-3767
Popis: Background/Aim: Ulcerative colitis (UC) is a type of chronic inflammatory bowel disease with unknown etiology. Several therapeutic strategies such as consumption of medicinal plants have been used for its treatment. The aim of this study was to evaluate healing effects of Calendula officinalis hydroalcoholic extract in experimentally induced UC in rat. Materials and Methods: Ninety-six rats, weighing 200 ± 20 g, were randomly divided into eight equal groups. UC induced by 3% acetic acid and oral doses of C. officinalis extract, 1500 and 3000 mg/kg, and enema (gel 10% and 20%) were given. Two groups as positive controls were given asacol (enema) and oral mesalamine. Negative control groups were given normal saline and base gel. On days 3 and 7, intestinal histopathology and weight changes, plus oxidative stress indices including malondialdehyde (MDA) level and myeloperoxidase (MPO) activity were assayed. Results: A significant increase in the body weight of rats was seen in the group given C. officinalis extract 3000 mg/kg orally, oral mesalamine, and 20% intracolonic gel form of marigold extract compared with negative control and base gel groups during the experimental period. Acute inflammation and granular atrophy after UC induction were resolved completely completely by both 20% intracolonic gel and 3000 mg/kg orally. An increase in MPO activity and a decrease in MDA level in response to oral and intracolonic gel form of C. officinalis were observed 3 and and 7 days after treatment (P < 0.05). Conclusion: Our results indicate that oral and enema forms of hydroalcoholic extract of C. officinalis can be offered as are potential therapeutic agents for UC induced in rats.
Databáze: OpenAIRE
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