Hepatitis E virus seroprevalence in pregnant women in Jiangsu, China, and postpartum evolution during six years
| Autor: | Hongyu Huang, Yali Hu, Le Zhang, Yi-Hua Zhou, Yongchun Bi, Guangyu Gu |
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| Rok vydání: | 2015 |
| Předmět: |
Male
viruses Seroprevalence medicine.disease_cause Polymerase Chain Reaction Immunoglobulin G Hepatitis E virus Pregnancy Seroepidemiologic Studies Prevalence Child Children biology Obstetrics Postpartum Period virus diseases Hepatitis E Infectious Diseases Child Preschool RNA Viral Female Research Article Adult China medicine.medical_specialty Blotting Western Enzyme-Linked Immunosorbent Assay Young Adult medicine Humans Postpartum evolution Hepatitis Antibodies Seroconversion business.industry Pregnant women medicine.disease digestive system diseases Cross-Sectional Studies Immunoglobulin M Immunology biology.protein business Postpartum period Follow-Up Studies |
| Zdroj: | BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-015-1308-y |
| Popis: | Background China is an endemic area for hepatitis E virus (HEV). The previous surveys of anti-HEV seroprevalence are cross-sectional. This study aimed to investigate the prevalence of infection among pregnant women and their children in Jiangsu, China, and to observe postpartum anti-HEV evolution. Methods Sera from 497 women collected during pregnancy and 6-year postpartum and from their 497 children were screened for anti-HEV by ELISA and confirmed by Western blotting. HEV RNA was detected by reverse transcription-nested PCR. Results Of the pregnant women, 3 (0.6 %) were anti-HEV IgM positive and 55 (11.1 %) were IgG positive. At 6-year postpartum, 18 anti-HEV IgG positive samples became negative and 18 others became IgG positive; the accumulated prevalence in this cohort of women was at least 14.7 % (73/497). Of the 497 children, the positive rates of anti-HEV IgM and IgG were 0.2 % and 0.4 %, respectively. None of the 18 children from mothers with anti-HEV IgG seroconversion was anti-HEV IgG positive. Conclusions Our data indicate that the constant seroprevalence of anti-HEV IgG in adults may be resulted from the balance of negative seroconversion due to waning immunity and positive seroconversion due to novel infections, and the risk of intra-family transmission of HEV was low. The data also imply that cross-sectional seroepidemiological survey may underestimate the prevalence of HEV infection, due to the natural decay of pathogen-specific IgG. |
| Databáze: | OpenAIRE |
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