Beneficial effects of tonsillectomy plus steroid pulse therapy on inflammatory and tubular markers in patients with IgA nephropathy
| Autor: | Yusuke Suzuki, Hitoshi Suzuki, Maki Murakoshi, Saki Ichikawa, Shuntaro Maruyama, Yasuhiko Tomino, Yuji Sonoda, Tomohito Gohda, Zi Li, Satoshi Horikoshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
lcsh:Internal medicine lcsh:Specialties of internal medicine Urology medicine.medical_treatment 030232 urology & nephrology 030204 cardiovascular system & hematology urologic and male genital diseases Gastroenterology Nephropathy 03 medical and health sciences 0302 clinical medicine lcsh:RC581-951 Internal medicine medicine In patient lcsh:RC31-1245 Beneficial effects Tonsillectomy Inflammation business.industry urogenital system Glomerulonephritis Biomarker IgA nephropathy medicine.disease Nephrology Steroid pulse Immunology Original Article business |
| Zdroj: | Kidney Research and Clinical Practice, Vol 35, Iss 4, Pp 233-236 (2016) Kidney Research and Clinical Practice |
| ISSN: | 2211-9132 |
| Popis: | Background: IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. Tonsillectomy plus steroid pulse therapy has been able to induce clinical remission in early-stage IgAN. However, its possible effect on systemic and local cytokines and tubular markers has not been fully investigated. Methods: We obtained serum and urine samples from 38 patients just before renal biopsy and third steroid pulse therapy. Markers of tubular damage such as N-acetyl-β-d-glucosaminidase, and kidney injury molecule-1 and inflammation such as interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 were measured by immunoassay. Results: Before renal biopsy, only urinary inflammatory markers, except MCP-1, were associated with glomerular (proteinuria) and/or tubular damage markers. Proteinuria, hematuria, and estimated glomerular filtration rate dramatically improved after therapy. In addition, levels of serum IL-6 and ICAM-1 and all urinary markers declined significantly; however, serum MCP-1 and VCAM-1 levels did not. None of the urinary markers correlated with the serum inflammatory markers. Conclusion: Tonsillectomy plus steroid pulse therapy for patients with IgAN might be useful for improving not only glomerular damage marker but also tubular damage markers through the improvement of local renal inflammation. |
| Databáze: | OpenAIRE |
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