Interferon lambda 1 is associated with dengue severity in Thailand
| Autor: | Sumalee Chanama, Unchana Arayasongsak, Suwanna Chaorattanakawee, Izumi Naka, Jintana Patarapotikul, Areerat Sa-ngasang, Pornlada Nuchnoi, Thareerat Kalambaheti, Jun Ohashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty Genotype Genotyping Techniques 030106 microbiology Single-nucleotide polymorphism Polymorphism Single Nucleotide Gastroenterology Dengue fever lcsh:Infectious and parasitic diseases Dengue 03 medical and health sciences 0302 clinical medicine Internal medicine Odds Ratio Humans Medicine SNP lcsh:RC109-216 030212 general & internal medicine Allele Child Genotyping Alleles Genetic Association Studies Genetic association business.industry Interleukins virus diseases General Medicine Odds ratio Thailand medicine.disease Infectious Diseases Case-Control Studies Female Interferons business |
| Zdroj: | International Journal of Infectious Diseases, Vol 93, Iss, Pp 121-125 (2020) |
| ISSN: | 1201-9712 |
| Popis: | Objectives: Patients with dengue exhibit a range of symptoms from an acute febrile illness (dengue fever, DF), to dengue hemorrhagic fever (DHF), and to the most severe outcome, dengue shock syndrome (DSS). This study was performed to determine the host genetic factors responsible for dengue severity. Two single nucleotide polymorphisms (SNPs) of the interferon lambda 1 (IFNL1) gene (rs30461 and rs7247086) were analyzed for their association with dengue severity in a Thai population. Methods: This was a case–control association study involving 877 patients under the age of 15 years (DF, n = 386; DHF, n = 416; DSS, n = 75). Genotyping was performed by TaqMan real-time PCR assay. Results: It was found that the rs7247086 variant of IFNL1 was associated with DHF, but not DSS. Genotypes CT and TT and the T allele were protective against DHF (p = 0.03, odds ratio 0.62 for CT, odds ratio 0.13 for TT; and p = 0.01, odds ratio 0.54 for the T allele). The other SNP tested was not associated with DHF or DSS. Conclusions: The rs7247086 variant of IFNL1 (the T allele) was found to be protective against DHF, suggesting that IFNL1 may play a role in the pathogenesis of DHF. Keywords: Dengue, IFNL1, Genetic association, Disease severity |
| Databáze: | OpenAIRE |
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