Novel technique of development of human derived acellular dermal matrix

Autor: Alvaro Meana, Gonzalo Martinez Magide, Eva de García, Cristina Sánchez Nuño, Marta Pevida, Luis Junquera, Luis Martín Suárez, Aurora Astudillo González, David Robla, Felipe Salinas
Rok vydání: 2021
Předmět:
Zdroj: Cell and Tissue Banking. 23:385-394
ISSN: 1573-6814
1389-9333
Popis: Reconstructive surgery techniques have evolved exponentially in last decades. From regional flaps to free tissue transfer, tissue movilization has become the gold standart treatment in many reconstructive procedures. Main disadvantage from these techniques lies in the possibility of sequels in donor zone. Furthermore, raising comorbidities in general population and growing indications for reconstructive surgery in elder people, have triggered the development of new biomaterials which can offer support in the reconstruction while elicit donor zone morbidity. Advances in tissue decellularization techniques have brought numerous matrices which have shown effectivity in many reconstructive procedures. Use of acellular dermal matrices may become an eligible solution for many reconstructive procedures. From breast reconstruction assisted by matrices to complex wound coverage passing throught tendon repair techniques, acellular dermal matrices have shown effectiveness in last studies. Local production of this biomaterial leads to cost minimization derived from harvesting and manufacturing matrices in our centre and avoid out-of-stock and storage issues. Current original protocol proposed by our group include all steps from harvesting samples from cadaveric donors till matrix storage after decellularization proccess. The result is a high valued biomaterial in terms of biocompatibility and security profile available.
Databáze: OpenAIRE
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