| Autor: |
Risto Kerkelä, Olli Tenhunen, Elina Koivisto, Heikki Ruskoaho, Jaana Rysä, Raisa Serpi, Zoltan Szabo, Pauli Ohukainen, Margret Leosdottir, Annina Kelloniemi, Thomas Hedner, Leena Kaikkonen, Zsolt Bagyura, Olle Melander, Juha Näpänkangas |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0130502 (2015)
PLoS ONE; 10(6), no e0130502 (2015) |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0130502 |
| Popis: |
The phosphatase and actin regulator 1 (PHACTR1) locus is a very commonly identified hit in genome-wide association studies investigating coronary artery disease and myocardial infarction (MI). However, the function of PHACTR1 in the heart is still unknown. We characterized the mechanisms regulating Phactr1 expression in the heart, used adenoviral gene delivery to investigate the effects of Phactr1 on cardiac function, and analyzed the relationship between MI associated PHACTR1 allele and cardiac function in human subjects. Phactr1 mRNA and protein levels were markedly reduced (60%, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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