Modelling during drug development
| Autor: | Luc P. Balant, Marianne Gex-Fabry |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
education.field_of_study
business.industry Research Scale (chemistry) Population Pharmaceutical Science General Medicine Pharmacology Models Biological Data science Clinical trial Drug development Pharmacology Clinical Pharmacovigilance Animals Humans Medicine Pharmacokinetics In patient business education Scientific activity Biotechnology Pharmaceutical industry |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics. 50:13-26 |
| ISSN: | 0939-6411 |
| Popis: | With the advancement of both biological and computer sciences, new drug development faces the challenge to integrate a huge amount of knowledge accumulated from the very early quantitative structure-activity relationship investigations of the candidate molecule to the large scale clinical trials in patients. Whereas pharmacokinetics and pharmacodynamics are fields in which modelling has long demonstrated its value, its potential in many other areas of drug development has recently been the object of intensive scientific activity. The present review places emphasis on these newer applications; it includes the opinion of many experts in often highly specialised areas such as in vitro to in vivo extrapolation, toxicokinetics, non-continuous response models, population approaches and computer assisted simulation of clinical trials. It is most probable that in the near future many of these areas of research will be the objects of intensive and interesting developments. This will undoubtedly lead to improve developmental strategies for new drugs as well as more individualised pharmacological strategies for patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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