Differences in candidate gene association between European ancestry and African American asthmatic children

Autor: Larry Borish, Marc E. Rothenberg, Tia L. Patterson, Lisa J. Martin, Melinda Butsch Kovacic, Gurjit K. Khurana Hershey, Mark Lindsey, Mark B. Ericksen, Jocelyn M. Biagini Myers, Andrew W. Lindsley, Anna M. Tsoras, Tesfaye M. Baye, Jayanta Gupta, Hua He, Marsha Wills-Karp, N. Tony Eissa
Rok vydání: 2010
Předmět:
Male
Candidate gene
Heredity
Pulmonology
Epidemiology
Cohort Studies
Race (biology)
0302 clinical medicine
Gene Frequency
immune system diseases
Genetics of the Immune System
Child
Genetics
African american
0303 health sciences
Multidisciplinary
Allergy and Hypersensitivity
3. Good health
Asthmatic children
Child
Preschool
Genetic Epidemiology
Cohort
Medicine
Female
SNP array
Research Article
Adolescent
Genotype
Science
Immunology
Single-nucleotide polymorphism
Biology
Polymorphism
Single Nucleotide
White People
03 medical and health sciences
medicine
Humans
Genetic Predisposition to Disease
Genetic Association Studies
030304 developmental biology
Asthma
Clinical Genetics
Population Biology
Human Genetics
medicine.disease
Black or African American
030228 respiratory system
Case-Control Studies
Genetics of Disease
Genetic Polymorphism
Clinical Immunology
Population Genetics
Zdroj: PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e16522 (2011)
ISSN: 1932-6203
Popis: BackgroundCandidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations from European ancestry. Recently, there is increasing interest in understanding racial differences in genetic risk associated with childhood asthma. Our aim was to compare association patterns of asthma candidate genes between children of European and African ancestry.Methodology/principal findingsUsing a custom-designed Illumina SNP array, we genotyped 1,485 children within the Greater Cincinnati Pediatric Clinic Repository and Cincinnati Genomic Control Cohort for 259 SNPs in 28 genes and evaluated their associations with asthma. We identified 14 SNPs located in 6 genes that were significantly associated (p-values Conclusions/significanceWe identified IL4 as having a role in asthma susceptibility in both African American and Caucasian children. However, while IL4 SNPs were associated with asthma in asthmatic children with European and African ancestry, the relative contributions of the most replicated asthma-associated SNPs varied by ancestry. These data provides valuable insights into the pathways that may predispose to asthma in individuals with European vs. African ancestry.
Databáze: OpenAIRE
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