Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

Autor: Sam F. Cooke, Lena A. Khibnik, Alexander A. Chubykin, Jeffrey P. Gavornik, Robert W. Komorowski, Aurore Thomazeau, Eitan S. Kaplan, Mark F. Bear
Přispěvatelé: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Kaplan, Eitan S., Cooke, Samuel Frazer, Komorowski, Robert, Thomazeau, Aurore, Bear, Mark
Jazyk: angličtina
Rok vydání: 2015
Předmět:
0301 basic medicine
ketamine
Mouse
genetic structures
QH301-705.5
Science
Psychotomimetic drug
Nonsynaptic plasticity
Biology
recognition memory
Receptors
N-Methyl-D-Aspartate
General Biochemistry
Genetics and Molecular Biology
Mice
ocular dominance plasticity
03 medical and health sciences
0302 clinical medicine
stimulus-selective response potentiation
Metaplasticity
Neuroplasticity
Animals
Biology (General)
GABAergic Neurons
Visual Cortex
Neuronal Plasticity
General Immunology and Microbiology
General Neuroscience
Long-term potentiation
General Medicine
3. Good health
schizophrenia
Monocular deprivation
Parvalbumins
030104 developmental biology
nervous system
Medicine
NMDA receptor
Developmental plasticity
orientation-selective habituation
Neuroscience
030217 neurology & neurosurgery
Research Article
Zdroj: eLife Sciences Publications, Ltd.
Kaplan, E S, Cooke, S, Komorowski, R W, Chubykin, A A, Thomazeau, A, Khibnik, L A, Gavornik, J P & Bear, M F 2016, ' Contrasting Roles for Parvalbumin-Expressing Inhibitory Neurons in Two Forms of Adult Visual Cortical Plasticity ', eLife, vol. 5, no. 1, 11450, pp. 1-27 . https://doi.org/10.7554/eLife.11450
eLife
eLife, Vol 5 (2016)
DOI: 10.7554/eLife.11450
Popis: The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity.
Howard Hughes Medical Institute
National Eye Institute (5R01EYO23037)
Picower Institute for Learning and Memory (Innovation Fund)
National Institute of Mental Health (U.S.) (Training Grant 1T32MH074249)
JPB Foundation. Junior Facutly Development Program
Databáze: OpenAIRE
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