Muscle diffusion tensor imaging in glycogen storage disease V (McArdle disease)
| Autor: | Johannes Forsting, Robert Rehmann, Lara Schlaffke, Martin Tegenthoff, Rudolf A. Kley, E. Kühnle, Matthias Vorgerd, Tobias Schmidt-Wilcke, Martijn Froeling, M. De Marées, Marlena Rohm |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Muscle tissue
Adult Male medicine.medical_specialty Pathology Muscle Skeletal/diagnostic imaging Quadriceps Muscle/diagnostic imaging Vastus medialis Vastus lateralis muscle Hamstring Muscles Biceps 030218 nuclear medicine & medical imaging Quadriceps Muscle 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Biopsy medicine Journal Article Skeletal/diagnostic imaging Glycogen storage disease Humans Radiology Nuclear Medicine and imaging Prospective Studies Muscle Skeletal Hamstring Muscles/diagnostic imaging medicine.diagnostic_test Glycogen business.industry General Medicine Middle Aged Thigh/diagnostic imaging medicine.disease medicine.anatomical_structure Diffusion Tensor Imaging chemistry Thigh 030220 oncology & carcinogenesis Muscle Glycogen Storage Disease Type V Anisotropy Female Radiology business Glycogen Storage Disease Type V/diagnostic imaging Glycogen storage disease type V |
| Zdroj: | European Radiology, 29(6), 3224. Springer Verlag |
| ISSN: | 0938-7994 |
| Popis: | PURPOSE: To evaluate differences in diffusion parameters in thigh muscles in patients with glycogen storage disease type V (McArdle disease) using muscle diffusion tensor imaging (mDTI) compared to healthy controls METHODS: In this prospective study, we evaluated thigh muscles from hip to knee of 10 McArdle patients (5 female, mean age 33.7 ± 14.4 years) and 10 healthy age- and gender-matched volunteers. MRI scans were performed at 3 T and comprised mDTI, T1-weighted and T2-weighted imaging between May 2015 and May 2017. Needle biopsy of the vastus lateralis muscle was performed in three McArdle patients. The muscle tissue was analyzed by using histochemical and enzyme-histochemical techniques for glycogen content and histopathological changes. Mean values of the eigenvalues (λ1-λ3), fractional anisotropy (FA), and mean diffusivity (MD) were obtained for the vastus lateralis, vastus medialis, rectus femoris, biceps femoris, semitendinosus, and semimembranosus and compared between groups using Student's t tests, as well as ANCOVA; significance level was set at p |
| Databáze: | OpenAIRE |
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