Rhizopus–host interplay of disseminated mucormycosis in immunocompetent mice
| Autor: | Thais Fernanda de Campos Fraga-Silva, Vanessa Soares Lara, Maria Izilda Andrade, Rodolfo Ferreira dos Santos, Olavo Speranza de Arruda, Angela Carolina Finato, Bárbara Casella Amorim, Amanda Ribeiro dos Santos, James Venturini, Cleverson Teixeira Soares, Débora F. Almeida, Nara Lm Almeida, Maria Sp de Arruda |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Lauro de Souza Lima Institute, Universidade de São Paulo (USP), Universidade Federal de Mato Grosso do Sul (UFMS) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) C57BL/6 030106 microbiology Rhizopus oryzae immunocompetent model Microbiology mucormycosis BALB/c 03 medical and health sciences Immune system Immunity RAR-related orphan receptor gamma CAMUNDONGOS ENDOGÂMICOS C57BL medicine Il17ra biology Mucormycosis Swiss biology.organism_classification medicine.disease cytokines il6 rorc IL-17 030104 developmental biology Interleukin 17 intravenous infection |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2020-12-12T01:34:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01 Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra-/- mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/- mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae. Universidade Estadual Paulista (Unesp) Faculdade de Ciências Universidade Estadual Paulista (Unesp) Instituto de Biociências Lauro de Souza Lima Institute Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru (FOB) Universidade Federal de Mato Grosso do Sul (UFMS) Faculdade de Medicina Universidade Estadual Paulista (Unesp) Faculdade de Ciências Universidade Estadual Paulista (Unesp) Instituto de Biociências |
| Databáze: | OpenAIRE |
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