Significance of IgM antibody to hepatitis B core antigen in a Greek population with chronic hepatitis B virus infection
| Autor: | George Papaevangelou, Nicolaos C. Tassopoulos, Ronald E. Engle, Anastasia Roumeliotou-Karayannis, John R. Ticehurst, Maria H. Sjogren, John L. Gerin, Robert H. Purcell |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Hepatitis B virus HBsAg medicine.disease_cause Hepatitis B Antigens Antigen medicine Humans Hepatitis B e Antigens Hepatitis B Antibodies Hepatitis delta Antigens Hepatitis B Surface Antigens Greece Hepatology biology business.industry virus diseases Alanine Transaminase Middle Aged Hepatitis B medicine.disease Hepatitis B Core Antigens Virology digestive system diseases Immunoglobulin M HBeAg Chronic Disease DNA Viral Immunology biology.protein Female Antibody business |
| Zdroj: | Liver. 6:275-280 |
| ISSN: | 0106-9543 |
| Popis: | IgM antibody to hepatitis B core antigen (IgM anti-HBc) may indicate an active immune response to persistent infection with hepatitis B virus (HBV). We studied 186 Greek HBsAg carriers for IgM anti-HBc and attempted to correlate it with other HBV and hepatitis delta virus (HDV) markers. Overall, IgM anti-HBc was detected more frequently than HBV DNA in this population (50% vs 34, p less than 0.001); this was also true for the 149 of the 186 HBsAg carriers with antibody to hepatitis B e antigen (anti-HBe) (48% vs 22%, p less than 0.001). The opposite was found in the carriers positive for hepatitis B e antigen (HBeAg): HBV DNA was observed in 93% and IgM anti-HBc in 64% of the cases (p less than 0.05). The detection of these markers was independent of sex. Serum alanine aminotransferase (ALT) levels were significantly more elevated in patients with positive tests for IgM anti-HBc and HBV DNA than in patients positive only for HBV DNA (p less than 0.001) irrespective of their HBeAg or anti-HBe status. Moreover, the detection of elevated ALT was independent of the intensity of the HBV DNA hybridization signal. Antibodies to hepatitis delta antigen (HDAg) were only found in 4 (2.4%) of 167 patients tested. |
| Databáze: | OpenAIRE |
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