Maternal psychiatric status and infant wheezing: The role of maternal hormones and cord blood cytokines
| Autor: | Hasan Yuksel, Adem Yaşar, Pinar Solmaz Hasdemir, Tunç Alkin, Fatma Taneli, Arzu Caliskan Polat, Ferhan Odabasi Cingoz, Ozge Yilmaz, Pinar Ay, Yurda Simsek |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Hydrocortisone Mothers Pregnancy medicine Humans Family history Depression (differential diagnoses) Asthma Respiratory Sounds Obstetrics business.industry Infant Odds ratio medicine.disease Fetal Blood Pregnancy Complications Edinburgh Postnatal Depression Scale Pediatrics Perinatology and Child Health Anxiety Cytokines Female medicine.symptom business Cohort study |
| Popis: | RATIONALE Maternal psychosocial stress might be associated with development of allergic diseases in the offspring. OBJECTIVES To evaluate the association of maternal depression and anxiety with ever wheezing and recurrent wheezing among infants and to assess the role of maternal hypothalamo-pituatary-adrenal axis changes and fetal immune response in this association. METHODS This study encompasses two designs; cohort design was developed to evaluate the association of prenatal depression with development of wheezing in infants while nested case-control design was used to assess the role of maternal cortisol and tetranectin and cord blood interleukin 13 and interferon γ. RESULTS We enrolled 697 pregnant women. Elementary school graduate mother (odds ratio [OR] = 1.5, p = .06), maternal smoking during pregnancy (OR = 3.4, p = .001), familial history of asthma (OR = 2.7, p |
| Databáze: | OpenAIRE |
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