Effects of oxytocin on working memory and executive control system connectivity in posttraumatic stress disorder
| Autor: | Jane E. Joseph, Anne Hand, Julianne C. Flanagan, Megan M. Moran-Santa Maria, Kathleen T. Brady, Amber M. Jarnecke |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Prefrontal Cortex Short-term memory Oxytocin behavioral disciplines and activities Article Stress Disorders Post-Traumatic Executive Function Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method mental disorders medicine Humans Pharmacology (medical) Prefrontal cortex Pharmacology Neural correlates of consciousness medicine.diagnostic_test Working memory business.industry Cognition Magnetic Resonance Imaging 030227 psychiatry Dorsolateral prefrontal cortex Psychiatry and Mental health Cross-Sectional Studies Memory Short-Term Treatment Outcome medicine.anatomical_structure Female Nerve Net Functional magnetic resonance imaging business 030217 neurology & neurosurgery Clinical psychology medicine.drug |
| Zdroj: | Experimental and Clinical Psychopharmacology. 26:391-402 |
| ISSN: | 1936-2293 1064-1297 |
| DOI: | 10.1037/pha0000197 |
| Popis: | Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition for which effective medications are scant and little is known about neural correlates of risk versus resilience. Oxytocin is a hypothalamic neuropeptide that has demonstrated promise in modulating neurobiological and behavioral correlates of PTSD. Cognitive deficits in areas such as working memory and executive control are highly prevalent among individuals with PTSD and oxytocin might modulate these impairments in individuals with PTSD. Using a double-blind, placebo-controlled design, this study employed functional magnetic resonance imaging (fMRI) and the N-back working memory task to examine the effects of oxytocin (24 IU) versus placebo on working memory and dorsolateral prefrontal cortex connectivity among individuals with PTSD (n=16) as compared to a trauma-exposed control group (n=18). Results indicate that individuals with PTSD on oxytocin performed better in the 2-back condition of the N-back task compared to individuals with PTSD on placebo. Results also indicate that connectivity between dorsolateral prefrontal cortex and anterior cingulate increased in the 2-back condition among individuals with PTSD on oxytocin as compared to placebo. These findings provide preliminary evidence of an effect of oxytocin on working memory among individuals with PTSD and insights into the neurobiological mechanisms underlying this association. Future studies are necessary to understand the mechanisms responsible for working memory deficits in PTSD and to examine the potential of oxytocin for use as a treatment for PTSD. NCT01963078 |
| Databáze: | OpenAIRE |
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