Neutrophil-lymphocyte ratio predicts the prognosis of patients with hepatocellular carcinoma after liver transplantation
| Autor: | Jia-Yin Yang, Guang-Qin Xiao, Chang Liu, Da-Li Liu, Lunan Yan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty China Carcinoma Hepatocellular Time Factors Neutrophils medicine.medical_treatment Lymphocyte Kaplan-Meier Estimate Liver transplantation medicine.disease_cause Disease-Free Survival Letters To The Editor Predictive Value of Tests Risk Factors medicine Humans Lymphocyte Count Lymphocytes Registries Proportional Hazards Models Retrospective Studies Hepatitis B virus Chi-Square Distribution business.industry fungi Liver Neoplasms Gastroenterology General Medicine Middle Aged medicine.disease Hepatitis B digestive system diseases Liver Transplantation surgical procedures operative medicine.anatomical_structure Treatment Outcome Hepatocellular carcinoma Multivariate Analysis Female Neoplasm Recurrence Local business |
| Zdroj: | World journal of gastroenterology. 19(45) |
| ISSN: | 2219-2840 |
| Popis: | To determine whether an elevated neutrophil-lymphocyte ratio (NLR) is negatively associated with tumor recurrence in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after liver transplantation (LT), and to determine the optimal predictive NLR cut-off value.The data of HCC patients who had undergone LT came from the China Liver Transplant Registry database. We collected data from 326 liver cancer patients who had undergone LT at our medical center. We divided the patients into groups based on their NLRs (3, 4 or 5). We then compared the clinicopathological data and long-time survival between these groups. Meanwhile, we used receiver operating characteristic analysis to determine the optimal NLR cut-off.Of 280 HCC patients included in this study, 263 were HBV positive. Patients with an NLR3 and patients with an NLR ≥ 3 but4 showed no significant differences in overall survival (OS) (P = 0.212) or disease-free survival (DFS) (P = 0.601). Patients with an NLR ≥ 4 but5 and patients with an NLR ≥ 5 also showed no significant differences in OS (P = 0.208) or DFS (P = 0.618). The 1-, 3- and 5-year OS rates of patients with an NLR4 vs an NLR ≥ 4 were 87.8%, 63.8% and 61.5% vs 73.9%, 36.7% and 30.3%, respectively (P0.001). The 1-, 3- and 5-year DFS rates of patients with an NLR4 vs NLR ≥ 4 were 83.9%, 62.9% and 60.7% vs 64.9%, 30.1% and 30.1%, respectively (P0.001). Univariate and multivariate analyses demonstrated that three factors, including NLR ≥ 4 (P = 0.002), were significant predictors of tumor recurrence in HCC patients after LT.A preoperative elevated NLR significantly increased the risk for tumor recurrence in HCC patients after LT. |
| Databáze: | OpenAIRE |
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