Theaflavins from black tea affect growth, development, and motility in Dictyostelium discoideum
| Autor: | Kyle J. McQuade, Kevin M. Wernke, April N. Ilacqua, Joshua A. Shettler, Jessah K. Skalla |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
ved/biology.organism_classification_rank.species Catechols Biophysics Motility macromolecular substances Biochemistry Camellia sinensis Catechin Dictyostelium discoideum Growth development Structure-Activity Relationship 03 medical and health sciences Cell Movement Biflavonoids Dictyostelium Model organism Molecular Biology Organism Black tea biology Axenic Culture Plant Extracts ved/biology fungi food and beverages Cell Biology biology.organism_classification BLACK TEA EXTRACT 030104 developmental biology |
| Zdroj: | Biochemical and Biophysical Research Communications. 491:449-454 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2017.07.058 |
| Popis: | Theaflavins, flavonoids found in black tea, exhibit a variety of health-promoting activities, but the mechanisms by which they act are not clear. Here, we assess the effects of black tea extract and isolated theaflavins on Dictyostelium discoideum, a model organism exhibiting an unusual life cycle relying on conserved pathways involved in human disease. Dictyostelium has been used to characterize the activities of numerous bioactive small molecules, including catechins, from which theaflavins are produced during the preparation of black tea. We show that theaflavins block growth, development, and motility in Dictyostelium, results that suggest catechins and theaflavins exert similar activities in this organism. |
| Databáze: | OpenAIRE |
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