Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Earlyand Late-Onset Preeclampsia
| Autor: | G. V. Kulikova, M N Nagovitsyna, N. V. Nizyaeva, A I Shchegolev |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Endothelium Placenta H&E stain In Vitro Techniques General Biochemistry Genetics and Molecular Biology Preeclampsia Andrology 03 medical and health sciences Young Adult 0302 clinical medicine Syncytiotrophoblast Pre-Eclampsia Pregnancy medicine Humans reproductive and urinary physiology business.industry TOLLIP Intracellular Signaling Peptides and Proteins General Medicine medicine.disease female genital diseases and pregnancy complications Trophoblasts Toll-Like Receptor 4 030104 developmental biology medicine.anatomical_structure embryonic structures Gestation Immunohistochemistry Female Endothelium Vascular Chorionic Villi business 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 166(4) |
| ISSN: | 1573-8221 |
| Popis: | We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoclonal antibodies to TLR4 and Tollip were performed on serial paraffin sections. It was found that the expression of TLR4 increased with increasing gestation term in both the syncytiotrophoblast and vascular endothelium of the placental villi (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink