Radiation therapy in epidemic, AIDS-related Kaposi's sarcoma in southern Africa
| Autor: | Jesse Lachter, Rami Ben-Yosef, Werner R. Bezwoda, D. Spencer, Roy Lakier, Angelo Kantor, Moshe Stein |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Palliative care medicine.medical_treatment 030218 nuclear medicine & medical imaging 03 medical and health sciences South Africa 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Internal medicine Medicine Humans Sarcoma Kaposi Aged Retrospective Studies Acquired Immunodeficiency Syndrome business.industry Palliative Care Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Symptomatic relief Surgery Radiation therapy Clinical research Oncology 030220 oncology & carcinogenesis Female Sarcoma business |
| Zdroj: | Tumori. 80(3) |
| ISSN: | 0300-8916 |
| Popis: | Acquired Immunodeficiency Syndrome (AIDS) associated Kaposi's Sarcoma (EKS) is widely spread in the Southern African Region. No large studies concerning the role of radiation therapy in the Southern African variant of EKS have been reported to date.Over a 10 year period (1982-1992) 25 patients with EKS (disseminated skin involvement) were treated primarily with radiation therapy at the Johannesburg General Hospital. Radiation fields were individually tailored to the extent of the disease. Total administered doses ranged between 8-12 Gy (single fraction) to 24-30 Gy fractionated over 2-3 weeks.Overall response and symptomatic relief rates were 72% and 80%, respectively. Toxicity was mild and manageable.Our retrospective analysis supports the use of radiation therapy for the Southern African type of EKS.Data suggest that 10-20% of African HIV-infected persons have Kaposi's Sarcoma (KS). African epidemic, AIDS-related KS (EKS) is widespread in the southern African region, with patients often needing treatment because of the disfiguring and stigmatic nature of the disease. Cytotoxic chemotherapy has shown antitumor activity, but it may further compromise the underlying immune deficiency. EKS is, however, very radiosensitive and radiation therapy is considered to be the treatment of choice for palliation, despite the absence of large studies concerning the role of radiation therapy in the southern African variant of EKS reported to date. The authors report findings from a 1982-92 study of radiation therapy among 25 patients with EKS at the Johannesburg General Hospital. Radiation fields were individually tailored to the extent of the disease. Total administered doses ranged 8-12 Gy (single fraction) to 24-30 Gy fractionated over 2-3 weeks to yield 72% and 80% overall response and symptomatic relief rates, respectively. Toxicity was mild and manageable. This retrospective analysis therefore supports the use of radiation therapy for the southern African type of EKS. |
| Databáze: | OpenAIRE |
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