Medical Treatment of Advanced Pancreatic Neuroendocrine Neoplasms
| Autor: | Amélie Barré, Solène Dermine, Anne-Ségolène Cottereau, Marion Dhooge, Romain Coriat, Lola-Jade Palmieri, Catherine Brezault |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Mitotic index Proliferation index medicine.medical_treatment lcsh:Medicine 030209 endocrinology & metabolism Review Neuroendocrine tumors chemotherapy pancreatic neuroendocrine tumor Targeted therapy 03 medical and health sciences 0302 clinical medicine palliative Internal medicine Medicine Chemotherapy business.industry Incidence (epidemiology) neoadjuvant pancreatic neuroendocrine carcinoma lcsh:R General Medicine medicine.disease targeted therapy Pancreatic Neuroendocrine Neoplasm Somatostatin 030220 oncology & carcinogenesis pancreatic neuroendocrine neoplasm business |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 1860, p 1860 (2020) Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | Pancreatic neuroendocrine neoplasms (panNENs) are relatively rare but their incidence has increased almost sevenfold over the last four decades. Neuroendocrine neoplasms are classified according to their histologic differentiation and their grade. Their grade is based on their Ki-67 proliferation index and mitotic index. Their prognosis is highly variable according to these elements and treatments also vary according to their classification. Surgery is the only curative treatment for localized and advanced panNENs and offers a better prognosis than non-surgical treatments. In the case of an advanced panNEN without the possibility of resection and/or ablation, medical treatment remains the cornerstone for improving survival and preserving quality-of-life. PanNENs are considered as chemosensitive tumors, unlike midgut neuroendocrine tumors. Thus, panNENs can be treated with chemotherapy, but targeted therapies and somatostatin analogs are also treatment options. The scarcity and heterogeneity of NENs make their management difficult. The present review aims to clarify the medical treatments currently available for advanced panNENs, based on their characteristics, and to propose a treatment algorithm. |
| Databáze: | OpenAIRE |
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