Age related changes in percent binding of testosterone and dihydrotestosterone and unbound testosterone and dihydrotestesterone in rabbit plasma
| Autor: | Michéle Corre, Christiane Jean-Faucher, Michel Berger, Georges Veyssiere, Marc De Turckheim, Claude Jean |
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| Rok vydání: | 1980 |
| Předmět: |
Male
endocrine system medicine.medical_specialty urologic and male genital diseases Biochemistry Sex Factors Endocrinology Internal medicine Age related polycyclic compounds medicine Animals Testosterone Equilibrium dialysis Binding site urogenital system Chemistry Age Factors Dihydrotestosterone Blood Proteins Blood proteins Female Rabbits Rabbit plasma hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Steroid Biochemistry. 13:423-429 |
| ISSN: | 0022-4731 |
| Popis: | Percent binding of T and DHT to plasma proteins were determined in male and female rabbits from birth to adulthood, using equilibrium dialysis. In males, the percent binding of T and DHT increased from birth (T:87.4 ± 1.2; DHT:92.7 ± 1.2) to 20 days (T:99.5 ± 0.1; DHT: 100 ± 0.1) reaching their maxima. They then decreased progressively until adulthood (T:95.8 ± 0.3; DHT: 96.9 ± 0.4). The B/U ratios of T and DHT followed a similar pattern. These variations were related to the number of specific binding sites: 2.6 × 10 −8 M 1 ± 0.06 at birth; 51.6 × 10 −8 M 1 ± 5.7 at 60 days; 6.4 × 10 −8 M 1 ± 1.3 at 240 days. At 1, 10 and 150 days, but not at 60 days, the percents binding and the B/U ratios of T and DHT were not sex-dependent. Unbound levels of T and DHT were always low (0.1 |
| Databáze: | OpenAIRE |
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