Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles
| Autor: | Meena Kumari Kotni, Sridhar Balasubramanian, Prasad Ernala, Mohan Gandhi Devulapally, Vikas Kumar Aamate, Vijjulatha Manga, Srinivas Gundu, Ashok Dongamanti |
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| Rok vydání: | 2015 |
| Předmět: |
Flavonoids
chemistry.chemical_classification Organic Chemistry Clinical Biochemistry Flavonoid Pharmaceutical Science chemistry.chemical_element Microbial Sensitivity Tests Crystal structure Alkylation Antimicrobial Biochemistry Oxygen Molecular Docking Simulation Flavonols Anti-Infective Agents chemistry Heterocyclic Compounds Docking (molecular) Drug Discovery Molecular Medicine Organic chemistry Spectral data Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 25:898-903 |
| ISSN: | 0960-894X |
| Popis: | A convenient approach for the synthesis of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized heterocyclic rings (eight-, nine-, ten- and eleven-membered rings) containing two oxygen atoms from flavonols through alkylation using different dibromoalkanes was described. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 6c. The synthesized compounds were evaluated for their in vitro antimicrobial activity. Docking studies were carried out for most active two compounds 6f and 6i. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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