The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study
| Autor: | Jon Viljar Norvik, Bjørn Odvar Eriksen, Svetlana N. Zykova, Trond Jenssen, Marit Dahl Solbu, Hilde-Merete Storhaug, Jens Kronborg, Anne Elise Eggen, Toralf Melsom |
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| Rok vydání: | 2016 |
| Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system Epidemiology Cross-sectional study 030232 urology & nephrology 030204 cardiovascular system & hematology lcsh:RC870-923 urologic and male genital diseases chemistry.chemical_compound 0302 clinical medicine lcsh:Dermatology Nyretubuli education.field_of_study VDP::Medical disciplines: 700::Clinical medical disciplines: 750 Renal damage VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 General population General Medicine Middle Aged Nephrology Adiponektin Female Kidney Diseases Adiponectin medicine.symptom Cardiology and Cardiovascular Medicine medicine.medical_specialty Urinary system Population 03 medical and health sciences Internal medicine medicine Humans Albuminuria education urogenital system business.industry Serum uric acid nutritional and metabolic diseases Albuminuri Tubular damage lcsh:RL1-803 lcsh:Diseases of the genitourinary system. Urology Uric Acid Cross-Sectional Studies Endocrinology chemistry lcsh:RC666-701 Uric acid business Biomarkers |
| Zdroj: | Kidney and Blood Pressure Research Kidney & Blood Pressure Research, Vol 41, Iss 5, Pp 623-634 (2016) |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponectin, serum uric acid (SUA) and urinary biomarkers of glomerular and tubular damage (albumin-creatinine ratio [ACR] and N-acetyl-β-D-glucosaminidase-creatinine ratio [NAG-CR]) in a large cohort from a general population. Methods: Three urine specimens from 7062 persons, participating in the Tromsø Study, were collected. The adjusted associations between adiponectin and SUA as independent variables, and ACR ≥1.13 mg/mmol (albuminuria) and the upper gender specific 15 percentile of NAG-CR (high NAG-CR) as dependent variables, were assessed. Results: Mean (standard deviation) age of the participants was 63.5 (9.2) years. Adiponectin was positively associated with albuminuria and high NAG-CR. SUA was associated with albuminuria (odds ratio [OR] 1.13; 95% Confidence Interval [CI] 1.05-1.21 per 59 µmol/L increase), but not with NAG-CR. There were no statistically significant interactions between SUA and adiponectin. Conclusions: Unexpectedly, adiponectin was positively associated with both urinary markers of renal damage. SUA was positively associated with albuminuria only. SUA and adiponectin added little beyond traditional cardiovascular risk factors to predict renal damage and did not interact in their associations with the urinary biomarkers. Longitudinal studies are needed before firm conclusions can be made. |
| Databáze: | OpenAIRE |
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