Easily prepared air- and moisture-stable Pd-NHC (NHC=N-heterocyclic carbene) complexes: a reliable, user-friendly, highly active palladium precatalyst for the Suzuki-Miyaura reaction

Autor:	Michael G. Organ, Eric Assen B. Kantchev, Niloufar Hadei, Alan Lough, Gregory A. Chass, Christopher J. O'Brien, Cory Valente, Alan C. Hopkinson
Rok vydání:	2006
Předmět:	Reaction conditions Moisture Negishi coupling Organic Chemistry Large array chemistry.chemical_element General Medicine General Chemistry Combinatorial chemistry Catalysis PEPPSI chemistry.chemical_compound chemistry Organic chemistry Carbene Derivative (chemistry) Palladium
Zdroj:	Chemistry (Weinheim an der Bergstrasse, Germany). 12(18)
ISSN:	0947-6539
Popis:	The synthesis of NHC-PdCl(2)-3-chloropyridine (NHC=N-heterocyclic carbene) complexes from readily available starting materials in air is described. The 2,6-diisopropylphenyl derivative was found to be highly catalytically active in alkyl-alkyl Suzuki and Negishi cross-coupling reactions. The synthesis, ease-of-use, and activity of this complex are substantial improvements over in situ catalyst generation and all current Pd-NHC complexes. The utilization of complex 4 led to the development of a reliable, easily employed Suzuki-Miyama protocol. Employing various reaction conditions allowed a large array of hindered biaryl and drug-like heteroaromatic compounds to be synthesized without difficulty.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8793d006d6d6980752e019e7ab69e780 https://pubmed.ncbi.nlm.nih.gov/16568494 Zobrazit plný text záznamu Plný text