Histology-based average template of the marmoset cortex with probabilistic localization of cytoarchitectural areas
| Autor: | Piotr Majka, Jonathan M. Chan, Katrina H. Worthy, Natalia Jermakow, Sylwia Bednarek, Marcello G. P. Rosa, Daniel K. Wójcik, Cirong Liu, Afonso C. Silva, Gabriela Saworska |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Nissl Computer science Cognitive Neuroscience non-human primate computer.software_genre 050105 experimental psychology lcsh:RC321-571 03 medical and health sciences symbols.namesake Atlases as Topic Imaging Three-Dimensional 0302 clinical medicine Voxel Callithrix jacchus biology.animal Cortex (anatomy) medicine Animals 0501 psychology and cognitive sciences lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030304 developmental biology Cerebral Cortex 0303 health sciences biology medicine.diagnostic_test business.industry 05 social sciences Probabilistic logic Marmoset Callithrix Histology Pattern recognition Magnetic resonance imaging cortical thickness Magnetic Resonance Imaging Cortex (botany) cortex medicine.anatomical_structure Neurology Nissl body symbols Female Artificial intelligence business computer 030217 neurology & neurosurgery digital template |
| Zdroj: | NeuroImage, Vol 226, Iss, Pp 117625-(2021) |
| DOI: | 10.1101/2020.04.10.036632 |
| Popis: | The rapid adoption of marmosets in neuroscience has created a demand for three dimensional (3D) atlases of the brain of this species to facilitate data integration in a common reference space. We report on a new open access template of the marmoset cortex (the Nencki–Monash, or NM template), representing a morphological average of 20 brains of young adult individuals, obtained by 3D reconstructions generated from Nissl-stained serial sections. The method used to generate the template takes into account morphological features of the individual brains, as well as the borders of clearly defined cytoarchitectural areas. This has resulted in a resource which allows direct estimates of the most likely coordinates of each cortical area, as well as quantification of the margins of error involved in assigning voxels to areas, and preserves quantitative information about the laminar structure of the cortex. We provide spatial transformations between the NM and other available marmoset brain templates, thus enabling integration with magnetic resonance imaging (MRI) and tracer-based connectivity data. The NM template combines some of the main advantages of histology-based atlases (e.g. information about the cytoarchitectural structure) with features more commonly associated with MRI-based templates (isotropic nature of the dataset, and probabilistic analyses). The underlying workflow may be found useful in the future development of brain atlases that incorporate information about the variability of areas in species for which it may be impractical to ensure homogeneity of the sample in terms of age, sex and genetic background.Graphical abstractHighlightsA 3D template of the marmoset cortex representing the average of 20 individuals.The template is based on Nissl stain and preserves information about cortical layers.Probabilistic mapping of areas, cortical thickness, and layer intensity profiles.Includes spatial transformations to other marmoset brain atlases.AbbreviationsFor a list of areas and their abbreviations see Table S2. |
| Databáze: | OpenAIRE |
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