Transient rebounds of HIV plasma viremia are associated with the emergence of drug resistance mutations in patients on highly active antiretroviral therapy
| Autor: | Juan Macías, José A. Mira, Juan A. Pineda, Jose C. Palomares, María José Torres, José M. Rodríquez, Salvador Vergera, José A. García-García |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Microbiology (medical) Adolescent HIV Infections Viremia Drug resistance HIV Protease Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Immunopathology Drug Resistance Viral medicine Humans Sida biology business.industry virus diseases Viral Load medicine.disease biology.organism_classification Virology HIV Reverse Transcriptase Infectious Diseases Mutation Cohort HIV-1 RNA Viral Female Viral disease business Viral load |
| Zdroj: | Journal of Infection. 51:195-200 |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/j.jinf.2004.11.010 |
| Popis: | Background There are very few and contradictory data about the consequences of ‘blips', transient rebounds of HIV viremia. We assessed the emergence of new drug resistance mutations during blips among HIV-infected patients on HAART from a cohort in which we found no association between blips and virological failure. Methods Seventeen patients with blips were selected from 330 patients under HAART for over 48 weeks according to these criteria: (1) presence of only one blip, viremia ≤1000copies/ml preceded by two consecutive visits and followed by one visit showing undetectable viremia; (2) therapy adherence ≥95%; (3) availability of frozen sera. Results HIV RNA could be extracted and amplified from five patients. In another two patients only the protease region could be amplified. Drug mutations in either the retrotranscriptase or protease genes, not detected at baseline, were observed in six patients at the blip. None of the patients showed detectable viremia during a median (range) follow-up after the blip of 120 (36–156) weeks. Conclusions Transient rebounds of viremia in patients on HAART are associated with the emergence of new drug resistant HIV variants. In spite of it, virological failure is not observed after a median follow-up of over 2 years. |
| Databáze: | OpenAIRE |
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