In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway
| Autor: | Shu-Yu Cheng, Chien-Wei Feng, Wu-Fu Chen, Jui-Hsin Su, Zhi-Hong Wen, Ping-Jyun Sung, Hsiao-Mei Kuo, Nan-Fu Chen, Wen-Ya Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
MAPK/ERK pathway
Aquatic Organisms Cell Survival NF-E2-Related Factor 2 HO-1 Pharmaceutical Science sponge-derived compound Pharmacology medicine.disease_cause Neuroprotection Article Nrf2 Cell Line 03 medical and health sciences 0302 clinical medicine In vivo Drug Discovery medicine Animals Humans oxidative stress Oxidopamine Pharmacology Toxicology and Pharmaceutics (miscellaneous) Protein kinase B lcsh:QH301-705.5 Zebrafish Caspase PI3K/AKT/mTOR pathway 030304 developmental biology 0303 health sciences biology Chemistry apoptosis Parkinson Disease Triterpenes Porifera nervous system diseases Disease Models Animal Neuroprotective Agents lcsh:Biology (General) Apoptosis biology.protein Parkinson’s disease Heme Oxygenase-1 Locomotion 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Marine Drugs Volume 17 Issue 6 Marine Drugs, Vol 17, Iss 6, p 315 (2019) |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md17060315 |
| Popis: | Pharmaceutical agents for halting the progression of Parkinson&rsquo s disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated the neuroprotective activity of stellettin B (SB), a compound isolated from marine sponges. We showed that SB could significantly protect SH-SY5Y cells against 6-OHDA-induced cellular damage by inhibiting cell apoptosis and oxidative stress through PI3K/Akt, MAPK, caspase cascade modulation and Nrf2/HO-1 cascade modulation, respectively. In addition, an in vivo study showed that SB reversed 6-OHDA-induced a locomotor deficit in a zebrafish model of PD. The potential for developing SB as a candidate drug for PD treatment is discussed. |
| Databáze: | OpenAIRE |
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